Head of the Group
Marina Sergeeva
Group of Lipid Systems Biology
A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia

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Scientific interests
People
Publications
Collaborations
Supplementaries

2010

Ivliev AE, ‘t Hoen PA, Sergeeva MG. Coexpression-based analysis of transcriptome organization provides insight into molecular heterogeneity and pathogenesis of glial tumors. Submitted.

Sergeeva MG, Aleshin SE, Grabeklis S, Reiser G. PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A(2) in astrocytes: inhibition in naive, untreated cells and enhancement in LPS-stimulated cells. J Neurochem. 2010 Jul 28.

Ivliev AE, Rudneva VA, Sergeeva MG. Applicability of coexpression networks analysis to anticancer drug targets discovery. Molecular Biology (Moscow), 2010. 44(2):366-74.

2009

Aleshin S, Grabeklis S, Hanck T, Sergeeva M, Reiser G. PPAR{gamma}positively and PPAR{alpha} negatively control COX-2 expression in rat brain astrocytes through a convergence on PPAR{beta}/{delta} via mutual control of PPAR expression levels. Mol Pharmacol. 2009 May 29.

2008

Ivliev AE, Sergeeva MG. OrthoFocus: program for identification of orthologs in multiple genomes in family-focused studies. J Bioinform Comput Biol. 2008 Aug;6(4):811-24.

Ivliev AE, 't Hoen PA, Villerius MP, den Dunnen JT, Brandt BW. Microarray retriever: a web-based tool for searching and large scale retrieval of public microarray data. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W327-31.

2007

Strokin M, Sergeeva M, Reiser G. Prostaglandin synthesis in rat brain astrocytes is under the control of the n-3 docosahexaenoic acid, released by group VIB calcium-independent phospholipase A2. J Neurochem. 2007 Sep;102(6):1771-82.

Ю.О. Каратассо, С.Е. Алёшин, Н.В. Попова, В.В. Чистяков, М.Г. Сергеева, С.Д. Варфоломеев. Количественный анализ простагландинов и полиненасыщенных жирных кислот методом масс-спектрометрии с ионизацией электрораспылением. Масс-спектрометрия. 2007 Сент;4(3):173-8.

2005

Bogatcheva NV, Sergeeva MG, Dudek SM, Verin AD.ВВ Arachidonic acid cascade in endothelial pathobiology. Microvasc Res. 2005 May;69(3):107-27. Review.

Sergeeva M, Strokin M, Reiser G. Regulation of intracellular calcium levels by polyunsaturated fatty acids, arachidonic acid and docosahexaenoic acid, in astrocytes: possible involvement of phospholipase A2. Reprod Nutr Dev. 2005 Sep-Oct;45(5):633-46.

2004

Strokin M, Sergeeva M, Reiser G. Role of Ca2+-independent phospholipase A2 and n-3 polyunsaturated fatty acid docosahexaenoic acid in prostanoid production in brain: perspectives for protection in neuroinflammation. Int J Dev Neurosci. 2004 Nov;22(7):551-7.

2003

Vrzheshch PV, Batanova TA, Mevkh AT, Varfolomeev SD, Gazaeyan IG. (2003) A novel approach to distinguish between enzyme mechanisms: quasi-steady-state kinetic analysis of the prostaglandin H synthase peroxidaseВВ reaction. Biochem. J. 372, 713-724.

Sergeeva M, Strokin M, Wang H., Ubl J.J., Reiser G. (2003) Arachidonic acid in astrocytes blocks Ca(2+) oscillations by inhibiting store-operated Ca(2+) entry, and causes delayed Ca(2+) influx. Cell Calcium. 33(4):283-92.

Strokin M, Sergeeva M, Reiser G. (2003) Docosahexaenoic acid and arachidonic acid release in rat brain astrocytes is mediated by two separate isoforms of phospholipase A2 and is differently regulated by cyclic AMP and Ca2+. Br J Pharmacol. 139(5):1014-22.

2002

Sergeeva M, Strokin M, Wang H, Ubl JJ, Reiser G. Arachidonic acid and docosahexaenoic acid suppress thrombin-evoked Ca2+ response in rat astrocytes by endogenous arachidonic acid liberation. J Neurochem. 2002 Sep;82(5):1252-61.

2001

Strokin ML, Sergeeva MG, Mevkh AT, Varfolomeyev SD. Experimental and theoretical investigation of arachidonic acid uptake in macrophages. Biochemistry (Mosc). 2001 Mar;66(3):312-318.

2000

Strokin, M., Sergeeva, M., Mevkh, A. (2000) The influence of serum fatty acid binding proteins on arachidonic acid uptake by macrophages. Applied Biochemistry and Biotechnology 88(1-3), 195-200.

Sergeeva, M., Ubl, J.J., Reiser, G. Disruption of actin cytoskeleton in cultured rat astrocytes suppresses ATP- and bradykinin-induced [Ca2+]i oscillations by reducing the coupling efficiecy between Ca2+ release, capacitative Ca2+ entry, and store refilling. Neuroscience. 2000,v.97, pp.765-769.

Ubl, J.J., Sergeeva, M., Reiser, G. Desensitisation of protease-activated receptor-1 (PAR-1) in rat astrocytes: evidence for a novel mechanism for terminating Ca2+ signalling evoked by the tethered ligand, J. Physiology, 2000, v.525, pp.319-330.